Kidney weakness (A problem that can become serious)

Kidney Weakness (The Underestimate The kidneys clean the blood, regulate blood pressure, salt and water balance and produce important hormones. They do their work unnoticed, even if they are getting worse and worse. More and more people develop progressive kidney weakness without even suspecting it. In Europe, ten percent of adults already have a chronic kidney disease and in many cases are ultimately dependent on artificial blood washing (dialysis) or kidney transplants.

Note: This is a very important subject to deal with as we can avoid chronic diseases and even everything related to cancer.

Symptoms of kidney weakness

With increasing age, kidneys naturally become weaker. In addition, painkillers and numerous illnesses strain the detox organs. Symptoms that may indicate kidney problems are:

-high blood pressure

-sharp headache

-Water in the legs

-Skin that stretches

-Foam on the urine

For example, an autoimmune disease can lead to chronic inflammation of the kidneys, which increases blood pressure and causes severe headaches.

The following symptoms can often occur in the final stages of renal insufficiency:

-hypertension that can no longer be controlled

-Decrease in urine volume

-Water retention (edema)

-shortness of breath

-sickness

-vomiting

-loss of appetite

-irregular heartbeat

-lightheadedness

-drowsiness

-cramps

-coma

Risk factors for kidney weakness

Especially high blood pressure and diabetes damage the very fine vessels of the kidneys in the long run. In addition, inflammatory reactions often occur in fatty tissue, which also endanger the kidneys. Overweight also affects the kidneys – with serious consequences such as diabetes, cardiovascular disease and a lower life expectancy.

More and more children and adolescents are severely overweight and suffer from type 2 diabetes. They run the risk of being dependent on regular mechanical blood washing at the age of 30 to 45 – for the rest of their lives.

In people with severe overweight (obesity), several risk factors for kidney failure often come together. Also cigarettes, an unhealthy diet with lots of pork and pain killers taken over a longer period of time such as ibuprofen or diclofenac can massively damage the kidneys.

Examination for kidney weakness

A decreasing kidney function can be detected by blood and urine tests:

A first indication is provided by the creatinine level in the blood. Creatinine is a decomposition product of the acid creatine, which supplies the muscles with energy. It accumulates in the blood when the kidneys do not work sufficiently. However, the creatinine value only increases when the kidney function is already reduced by more than 50 percent.

Increased protein excretion in the urine also indicates kidney damage.

More sensitive are the more complex laboratory tests for the protein cystatin C and the urokinase receptor suPAR, which circulates freely in the blood and indicates a kidney problem long before the first symptoms appear.

treat kidney weakness

Renal damage can usually not be reversed. If kidney damage is detected in time, the progression of the disease can often be slowed down with medication and a diet.

Those suffering from diabetes, overweight and high blood pressure should therefore have their kidney values checked regularly. A lot of exercise and a healthy diet can at least help to ensure that the diseases do not worsen and thus delay possible kidney damage.

If the organ function has already fallen to less than ten percent, only artificial blood washing (dialysis) can usually help. The only alternative is kidney transplantation, but donor organs are scarce.

How the kidney filters the blood

In the kidneys, about three million kidney corpuscles filter pollutants from the blood. In the renal corpuscles, so-called foot cells form a special grid-like structure: Healthy foot cells allow small molecules such as water and nitrogen compounds to pass through, which are released with the urine.

Large molecules such as blood cells and proteins are not allowed to pass through and remain in the blood. In a diseased kidney, the lattice structure of the foot cells is much more permeable: the blood loses large molecules, for example important proteins and vitamins.

Kidney weakness: Search for a drug

Medical scientists at Greifswald University Hospital use larvae of zebrafish to test substances that might be able to cure kidney diseases. In contrast to humans, zebrafish have only one renal body. The scientists use a special microscope to observe the renal corpuscles and the effect of the drugs.

Within a few hours they can see whether a drug has a positive or negative effect on the renal body of the zebrafish. So far, eleven active substances have been tested – without success. Even if experiments on zebrafish discover an active substance: It usually takes 10 to 15 years for a drug to be approved.

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